Do Environmental Factors Modify the Genetic Risk of Prostate Cancer?
نویسندگان
چکیده
منابع مشابه
Do Environmental Factors Modify the Genetic Risk of Prostate Cancer?
From the Department of Urology and Population Health, New York University, New York, NY, the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, the Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimo...
متن کاملRe: Do environmental factors modify the genetic risk of prostate cancer?
BACKGROUND Many SNPs influence prostate cancer risk. To what extent genetic risk can be reduced by environmental factors is unknown. METHODS We evaluated effect modification by environmental factors of the association between susceptibility SNPs and prostate cancer in 1,230 incident prostate cancer cases and 1,361 controls, all white and similar ages, nested in the Prostate, Lung, Colorectal,...
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There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK2/3. The MSMB and K...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2014
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-14-0786-t